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January 1982

Typhoid Hepatitis With Immunoglobulins and Complement Deposits in Bile Canaliculi

Author Affiliations

From the Department of Medicine (Drs Dan, Jedwab, and Shibolet) and the Division of Gastroenterology (Dr Bar-Meir), Ichilov Hospital, Tel-Aviv, Israel. Dr Dan is now with the University of Alberta, Edmonton.

Arch Intern Med. 1982;142(1):148-149. doi:10.1001/archinte.1982.00340140150027

• Documented typhoid fever in a 26-year-old patient was complicated by acute hepatitis with unusually profound jaundice. Liver biopsy revealed focal cell necrosis, mononuclear cell infiltration, Kupffer cell proliferation, and mild cholestasis. Immunofluorescent studies of the liver biopsy revealed deposits of IgG, IgA, IgM, and C3 in the bile canaliculi, suggesting a role for damage by immune complexes in typhoid hepatitis.

(Arch Intern Med 1982;142:148-149)