March 1982

Abnormal Serum Transaminase Levels in Patients With Hemophilia A

Author Affiliations

From the Department of Medicine, The Memorial Hospital and the University of Massachusetts Medical School, Worcester (Drs Cederbaum and Levine); and the Department of Medicine, University of North Carolina Medical Center, Chapel Hill (Dr Blatt).

Arch Intern Med. 1982;142(3):481-484. doi:10.1001/archinte.1982.00340160065016

In a cooperative study of 1,332 hemophiliacs, the results of a variety of liver function tests were correlated with the intensity and type of exposure to plasma products. After three sets of measurements at six-month intervals, 72% of patients had at least one abnormal transaminase value and 21.1% and 23.6% of patients had persistently elevated SGOT and SGPT levels, respectively, on all three measurements. Patients who had received no factor VIII during the previous year had fewer abnormalities than treated patients. Only those treated patients who received less than 50 units of factor VIII per kilogram per six months had fewer transaminase abnormalities if they used cryoprecipitate than if they used concentrate, but these patient groups are not strictly comparable, in that the cryoprecipitate-treated group contained a higher proportion of patients with mild hemophilia than did the concentrate-treated group.

(Arch Intern Med 1982;142:481-484)