March 1982

A Hypereosinophilic Syndrome With Retinal Arteritis and Tuberculosis

Author Affiliations

From the Departments of Hematology (Drs Farcet, Kuentz, Nass, and Ferret), Ophthalmology (Dr Binaghi), and Nephrology (Dr Nebout), Hôpital Henri Mondor, Créteil, France; and the Department of Central Anatomy and Pathology (Dr Merlier) and Center for Pneumology (Dr Mayaud), Hôpital Tenon, Paris.

Arch Intern Med. 1982;142(3):625-627. doi:10.1001/archinte.1982.00340160205034

• A 35-year-old man was initially seen with a decrease in visual acuity, renal insufficiency, and elevation of the eosinophil count in the blood. The ocular syndrome was caused by extensive arterial occlusions of the retina. The subsequent apparition of cardiac, pulmonary, and neurologic signs fulfilled the criteria for the diagnosis of hypereosinophilic syndrome (HES). Most symptoms, including ocular, were temporarily but notably improved by hydroxyurea. The patient died after two years. An autopsy showed an endomyocardial fibrosis and disclosed destruction of the left kidney by an active tuberculosis. A pathogenic relationship between the infectious disease and the HES is envisaged.

(Arch Intern Med 1982;142:625-627)