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Article
May 1982

Familial Bartter's Syndrome

Author Affiliations

From the Department of Medicine and Geriatrics, Osaka University Medical School, Fukushima-ku, Osaka, Japan. Dr Nugent is now with the University of Arizona, Tucson.

Arch Intern Med. 1982;142(5):906-908. doi:10.1001/archinte.1982.00340180064015
Abstract

• Two sisters were found to have Bartter's syndrome. Both had hypokalemia, hyperreninemia, normal BPs, and decreased pressor responses to angiotensin II. During a water diuresis, patient 1 had an abnormally low distal tubular fractional reabsorption of chloride initially, but this normalized after hypokalemia was corrected for one year. Patient 2 had no demonstrable defect in chloride transport. Hypokalemia in Bartter's syndrome may be caused by some hereditary mechanisms other than defective reabsorption of chloride in the distal tubules.

(Arch Intern Med 1982;142:906-908)

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