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May 1982

Hemophilic Osteoarthropathy

Author Affiliations

Halstead, Kan

Arch Intern Med. 1982;142(5):1041. doi:10.1001/archinte.1982.00340180199033

To the Editor.  —Control of the inflammation and pain of chronic hemophilic osteoarthropathy is a major goal in the treatment of patients with the hemophilias. Many analgesics have been used, but most patients suffer from adverse effects, eg, tolerance or physiologic addiction. Others have deleterious effects on platelet function, an undesirable phenomenon in a hemophiliac. Administration of ibuprofen at a dosage of 400 mg orally three to four times a day has been shown to be moderately effective in treating this disorder, with inconstant changes in bleeding times and no increased incidence of clinical bleeding.1 This moderate efficacy and lack of notable change in bleeding time parallel our experience at the Hertzler Clinic Hemophilia Treatment Center, Halstead, Kan.Zomepirac sodium is an effective nonnarcotic analgesic agent that inhibits prostaglandin synthesis. It has been shown to prolong bleeding times slightly in healthy volunteers but never out of the range of

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