A 62-year-old man with a typical history of gout was admitted to the hospital with left-sided hemiplegia. His serum uric acid level was 10.3 mg/dL, his partial thromboplastin time was 198 s, and his Hageman factor (factor XII) coagulant activity and antigen were less than 1% of normal. Aspiration of synovial fluid from his inflamed knee disclosed urate crystals and abundant leukocytes but an absence of Hageman factor antigen. The presence of acute gouty arthritis in a patient with Hageman trait challenges the role of Hageman factor in the pathogenesis of gouty arthropathy.
(Arch Intern Med 1982;142:1556-1557)
Green D, Arsever CL, Grumet KA, Ratnoff OD. Classic Gout in Hageman Factor (Factor XII) Deficiency. Arch Intern Med. 1982;142(8):1556-1557. doi:10.1001/archinte.1982.00340210154028