October 1982

Hypouricemia due to an Increment in Renal Tubular Urate Secretion

Author Affiliations

From the Second Department of Medicine, Tokyo Medical and Dental University, School of Medicine (Drs Shichiri, Matsuda, Shiigai, and Takeuchi); and the Department of Medicine, Yokosuka Mutual Aid Hospital, Yokosuka City, Kanagawa, Japan (Dr Kanayama).

Arch Intern Med. 1982;142(10):1855-1857. doi:10.1001/archinte.1982.00340230097017

Two patients had hypouricemia due to increased uric acid clearance. Their daily urinary uric acid excretions were normal. In both patients, pyrazinamide decreased urinary uric acid clearance to almost normal while probenecid increased it markedly. No other renal tubular or metabolic abnormalities were found. The serum electrolytes and the urinary electrolytes excretions showed no abnormalities. It appears that increased secretion of uric acid in the renal tubule is most probably responsible for hypouricemia in these patients. This report adds to the list of hypouricemic conditions due to a new isolated renal tubular abnormality.

(Arch Intern Med 1982;142:1855-1857)