October 1982

Apparent Ketoconazole Failure in Candidal Cholecystitis

Author Affiliations

From the Section on Infectious Diseases, Department of Medicine, Louisiana State University School of Medicine, New Orleans.

Arch Intern Med. 1982;142(10):1934-1935. doi:10.1001/archinte.1982.00340230182031

• Fungal acalculous cholecystitis is a rarely recognized complication of disseminated candidal infections. We report such a case of systemic candidiasis that developed in a man who was diabetic while he was receiving broad-spectrum antibiotic therapy for an infected foot ulcer. Ketoconazole, a new imidazole antifungal agent, was used successfully to treat the systemic candidal infection but it failed to eradicate the fungus in the biliary tract.

(Arch Intern Med 1982;142:1934-1935)