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Article
November 1982

Reversible Renal Insufficiency in Multiple Myeloma

Author Affiliations

From the Departments of Internal Medicine, University of Michigan and Veterans Administration Medical Center, Ann Arbor.

Arch Intern Med. 1982;142(12):2083-2086. doi:10.1001/archinte.1982.00340250041008
Abstract

• Forty-five patients met the criteria for the diagnosis of multiple myeloma in a retrospective chart review from 1975 to 1980. Renal insufficiency with peak serum creatinine concentration greater than 1.5 mg/dL involved 69% of all patients. Renal insufficiency was reversible in 55% of the cases. Treatment of hypercalcemia and/or chemotherapy for multiple myeloma was associated with reversibility in 88% of cases. Once renal insufficiency occurred in patients with multiple myeloma, those with reversible renal failure had a duration of survival fourfold longer (11.4 v 2.8 months) than those with Irreversible renal insufficiency. In conclusion, reversible renal insufficiency from hypercalcemia or the myeloma process itself develops in a majority of patients with multiple myeloma. If therapy reverses the renal dysfunction, a greater life expectancy occurs. Patients with multiple myeloma and renal insufficiency should, therefore, be examined for reversible causes of renal dysfunction, since if found and treated, a substantial improvement in prognosis is achieved.

(Arch Intern Med 1982;142:2083-2086)

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