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Article
January 1983

The Role of the Human Tumor Stem Cell Assay in Medical Oncology

Author Affiliations

From the Department of Internal Medicine, Rush-Presbyterian— St Luke's Medical Center, Chicago. Dr Johnson is now with the Carle Clinic, Urbana, Ill.

Arch Intern Med. 1983;143(1):111-114. doi:10.1001/archinte.1983.00350010117020
Abstract

• The human tumor stem cell assay is a technique that allows in vitro sensitivity testing of antineoplastic agents against cells from tumor specimens removed from patients. This assay predicts clinical response to drugs and permits Individualization of chemotherapy. It is more accurate in predicting drug resistance than drug sensitivity. Although there are technical problems with the assay, it has been successfully applied to nearly every possible type of human solid tumor and can be performed using cells from malignant effusions as well. Screening of new agents for activity against a range of human tumor specimens may prove to be the most important application of the human tumor stem cell assay.

(Arch Intern Med 1983;143:111-114)

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