January 1983

Acute Tumor Lysis in T-Cell Leukemia Induced by Amsacrine

Author Affiliations

From the Division of Hematology and Medical Oncology, Department of Medicine, Emory University School of Medicine, Atlanta.

Arch Intern Med. 1983;143(1):165-166. doi:10.1001/archinte.1983.00350010177034

• The acridine orange derivative amsacrine (National Services Center No. 249992) was used to treat a patient with T-cell acute lymphoblastic leukemia (ALL). A 17-year-old boy had a tumor lysis syndrome after a single 200 mg/sq m dose of amsacrine. This was followed by a prolonged period of marrow hypoplasia leading to death from infection. Review of the literature and our own experience would suggest that T-cell ALL may be exquisitely sensitive to amsacrine.

(Arch Intern Med 1983;143:165-166)