Claude Bernard, the great French physiologist, pointed out that the blood and the lymph, which bathe the cells of an organism, constitute the milieu interne or internal milieu of the organism. The internal milieu, a product of the organism and controlled by it, permits the organism to maintain desirable conditions for cells to function, despite external factors operating to disrupt or destroy homeostatic balance.1
See also p 309.
In selecting INTERNAL MILIEU as the title of a new department for the Archives, we had two objectives in mind. First, we wished to publish essays, stories, and vignettes that would express the character of the unique and rapidly changing environment of internal medicine and primary care today. This environment is the internal milieu of medical practice. Second, we believe the column will permit colleagues to share observations and insights. Third, we viewed the column as a forum for the discussion
Grouse LD, Soffer A. Internal Milieu. Arch Intern Med. 1983;143(2):214. doi:10.1001/archinte.1983.00350020032006