February 1983

Aprindine Therapy for Refractory Ventricular Tachycardia

Author Affiliations

From the Division of Cardiology, The Memorial Hospital, Pawtucket, RI, and the Department of Medicine, Brown University School of Medicine, Providence, RI.

Arch Intern Med. 1983;143(2):229-232. doi:10.1001/archinte.1983.00350020047010

• Aprindine hydrochloride has been extensively used in Europe for the management of ventricular and supraventricular arrhythmias. Success has been achieved even in those cases that have proven refractory to standard antiarrhythmic agents. In this report, we describe our experience with aprindine therapy in seven patients with ventricular tachycardia in whom standard antiarrhythmic agents had proven either ineffective or had caused intolerable side effects. Aprindine was effective in five cases, and it failed in two. Neurologic side effects, although common, were easily controlled with adjustment of the dose. Agranulocytosis, a rare but serious side effect, was encountered in one of our patients. Relevant literature on aprindine is reviewed.

(Arch Intern Med 1983;143:229-232)