February 1983

Nonobstructive Gastroparesis in Amyloidosis Improved With Metoclopramide

Author Affiliations

From the Division of Gastroenterology/Hepatology (Drs Reddy, Wright, and Nazer), and the Division of Immunology (Dr Wheeler), Department of Medicine, University of Louisville School of Medicine.

Arch Intern Med. 1983;143(2):247-248. doi:10.1001/archinte.1983.00350020069014

• Patients with systemic amyloidosis often have symptoms related to impaired gastrointestinal motility. Delayed gastric emptying may result from autonomic nerve and/or smooth-muscle infiltration with amyloid. In two patients with gastro-paresis secondary to amyloidosis, metoclopramide hydrochloride therapy quantitatively enhanced gastric emptying. We suggest that metoclopramide treatment may be useful in the supportive therapy of patients with delayed gastric emptying due to amyloidosis.

(Arch Intern Med 1983;143:247-248)