• Patients with systemic amyloidosis often have symptoms related to impaired gastrointestinal motility. Delayed gastric emptying may result from autonomic nerve and/or smooth-muscle infiltration with amyloid. In two patients with gastro-paresis secondary to amyloidosis, metoclopramide hydrochloride therapy quantitatively enhanced gastric emptying. We suggest that metoclopramide treatment may be useful in the supportive therapy of patients with delayed gastric emptying due to amyloidosis.
(Arch Intern Med 1983;143:247-248)
Reddy AB, Wright RA, Wheeler GE, Nazer H. Nonobstructive Gastroparesis in Amyloidosis Improved With Metoclopramide. Arch Intern Med. 1983;143(2):247–248. doi:10.1001/archinte.1983.00350020069014