March 1983

Successful Therapy for Rhinocerebral Mucormycosis With Associated Bilateral Brain Abscesses

Author Affiliations

From the Division of Infectious Diseases (Drs Oney and Crane) and the Department of Medicine (Dr Hamill), Wayne State University School of Medicine, Detroit.

Arch Intern Med. 1983;143(3):581-583. doi:10.1001/archinte.1983.00350030195037

• A case of extensive rhinocerebral mucormycosis, with associated bilateral brain abscesses, occurred in a man with diabetes. A Rhizopus sp grew from the initial nasal biopsy specimens. Successful therapy consisted of correcting metabolic acidosis, using serial computed tomographic (CT) scans to follow the progressive course of brain involvement from cerebritis to encapsulated abscesses, and performing successive biopsies to determine the adequacy of treatment. On 18-month follow-up, the patient had returned to full-time employment with minimal neurologic impairment. With CT scanning and aggressive therapy, rhinocerebral mucormycosis with bilateral brain involvement can be cured.

(Arch Intern Med 1983;143:581-583)