April 1983

Hepatitis and Jaundice Associated With Measles in Young AdultsAn Analysis of 65 Cases

Author Affiliations

From the Department of Medicine B (Drs Gavish, Kleinman, and Chajek-Shaul) and the Division of Clinical Virology (Dr Morag), Hadassah University Hospital, Jerusalem.

Arch Intern Med. 1983;143(4):674-677. doi:10.1001/archinte.1983.00350040064008

• We analyzed the clinical course of 65 adult patients hospitalized because of measles during the years 1975 and 1981-1982. Liver involvement was found in 80% (52/65) of the patients, five patients had clinical jaundice. The disturbances of liver function tests reached their peak values between days 5 and 10 of the disease. In this study of measles in adulthood we have three observations of unusual interest: (1) hepatitis occurs commonly in the more severely ill patients and it may manifest clinically as jaundice; (2) long-term follow-up (up to seven years) shows a clear tendency to complete resolution of the liver damage; (3) there is a clear correlation between the severity of hepatic involvement and the occurrence of secondary bacterial infections.

(Arch Intern Med 1983;143:674-677)