April 1983

Acute Myocardial Infarction in Sickle Cell Anemia

Author Affiliations

From the Departments of Pathology (Drs Martin, Cobb, and Tatter) and Medicine (Drs Johnson and Haywood), University of Southern California School of Medicine and the Los Angeles County-University of Southern California Medical Center, Los Angeles.

Arch Intern Med. 1983;143(4):830-831. doi:10.1001/archinte.1983.00350040220037

• Typical acute myocardial infarction in a well-documented case of sickle cell disease, to our knowledge, has not been reported. A patient with hemoglobin SS proved by electrophoresis with typical clinical manifestation and diagnostic ECG changes died suddenly. Autopsy findings were confirmatory, but no atherogenic lesions were present. Possible mechanisms for acute infarction are discussed, including sludging of sickle cells, coronary spasm, thrombus formation, and severe anemia associated with any or all of the aforementioned.

(Arch Intern Med 1983;143:830-831)