June 1983

Combined Treatment With Minoxidil and Captopril in Refractory Hypertension

Author Affiliations

From the Division of Hypertension and Clinical Pharmacology, the Department of Medicine, the University of Pittsburgh.

Arch Intern Med. 1983;143(6):1142-1144. doi:10.1001/archinte.1983.00350060064009

• The BP of four patients with severe hypertension could not be controlled by treatment with a variety of drugs including minoxidil and captopril. Satisfactory responses were obtained only when minoxidil and captopril were given in combination (along with diuretic and β-adrenergic blocking agents). The doses of minoxidil could be reduced by the addition of captopril and adverse effects were thus minimized. The state of the renin-angiotensin system prior to therapy was not a reliable predictor of the hypotensive response of the combination.

(Arch Intern Med 1983;143:1142-1144)