June 1983

Disseminated Varicella-Zoster Virus Infection With the Syndrome of Inappropriate Antidiuretic Hormone

Author Affiliations

From the Departments of Medicine (Drs Ingraham, Estes, and Bern) and Pathology (Dr DeGirolami), New England Deaconess Hospital, Harvard Medical School, Boston. Dr Ingraham is now with Boston Veterans Administration Hospital and Dr Estes is now with Massachusetts General Hospital, Boston.

Arch Intern Med. 1983;143(6):1270-1271. doi:10.1001/archinte.1983.00350060202037

• A patient with non-Hodgkin's lymphoma who was previously treated with chemotherapy and radiotherapy was seen with intestinal pseudoobstruction due to paralytic ileus associated with herpes zoster (varicella zoster) infection. The infection was accompanied by a polydermatomal rash with typical morphologic characteristics, followed by cutaneous dissemination and the syndrome of inappropriate antidiuretic hormone (SIADH), as well as myotomal paresis. The diagnosis was supported by cytology and by culture of the virus from the CSF. The isolation of the virus from the CSF, coupled with abnormalities of the patient's mental status and CSF, indicate that meningoencephalitis occurred and probably accounted for the SIADH. The patient had a spontaneous and complete recovery. To our knowledge, this is the first report of SIADH associated with herpes zoster infection.

(Arch Intern Med 1983;143:1270-1271)