• Thrombotic thrombocytopenic purpura (TTP) developed in a patient with seropositive rheumatoid arthritis (RA) after 2½ months of treatment with penicillamine. After discontinuation of the drug, plasmapheresis and steroid therapy led to a sustained remission. To our knowledge, no prior cases of penicillamine-induced TTP in RA have been reported.
(Arch Intern Med 1983;143:1487-1488)
Trice JM, Pinals RS, Plitman GI. Thrombotic Thrombocytopenic Purpura During Penicillamine Therapy in Rheumatoid Arthritis. Arch Intern Med. 1983;143(7):1487-1488. doi:10.1001/archinte.1983.00350070215039