September 1983

Treatment of Metastatic Pheochromocytoma With Streptozocin

Author Affiliations

From the Veterans Administration Medical Center and the Division of Endocrinology, Department of Medicine, Duke University Medical Center, Durham, NC.

Arch Intern Med. 1983;143(9):1799-1800. doi:10.1001/archinte.1983.00350090181033

• A 58-year-old man who had a malignant pheochromocytoma with hepatic metastasis was treated with 2 g/mo of Intravenous streptozocin for 18 months. There was a reduction in his urinary excretion of dopamine (from 33,840 to 731 μg/24 hr), homovanillic acid (from 48 to 8 mg/24 hr), and vanillylmandelic acid (from 350 to 74 mg/24 hr). There also was a reduction in the size of his hepatic metastasis (50%) and a right adrenal mass (25%), as well as a marked clinical improvement in his condition. Based on this evidence, I believe further attempts to treat patients with metastatic pheochromocytoma with streptozocin seem warranted.

(Arch Intern Med 1983;143:1799-1800)