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September 1983

Prolongation of the Prodrome to Acute Hepatitis B Infection by Corticosteroids

Author Affiliations

From the Department of Medicine, University of Kansas Medical Center, Kansas City.

Arch Intern Med. 1983;143(9):1810-1811. doi:10.1001/archinte.1983.00350090192037

• A 56-year-old woman had rash, arthralgia, and lymphadenopathy. Prednisone therapy caused the symptoms to abate but not disappear. Medication was continued for almost eight weeks, during which time the symptoms persisted. While the patient was receiving therapy, serologic evidence of hepatitis B infection was noted. When prednisone therapy was stopped, the patient rapidly passed from the prodrome to typical, acute, icteric hepatitis. Prednisone may have suppressed normal immunologic responses to the hepatitis virus, resulting in persistence of the serum sickness—like state. Corticosteroids are not indicated in the treatment of the prodrome to hepatitis B infection.

(Arch Intern Med 1983;143:1810-1811)