October 1983

Preliminary Immunologic Studies of Ciguatera Poisoning

Author Affiliations

From the Departments of Basic and Clinical Immunology and Microbiology (Drs Emerson, Galbraith, and Higerd) and Medicine (Dr Galbraith), Medical University of South Carolina, Charleston; College of the Virgin Islands, St Thomas (Dr McMillan); and the Charleston Laboratory, Southeast Fisheries Center, National Marine Fisheries Services NOAA, Charleston, SC (Dr Higerd).

Arch Intern Med. 1983;143(10):1931-1933. doi:10.1001/archinte.1983.00350100103021

• Preliminary immunologic studies of ciguatera poisoning were performed with serum samples from patients and extracts from both toxic and nontoxic fish. Counterimmunoelectrophoresis disclosed precipitin lines with toxic fish extracts and effectively discriminated between samples established as toxic or nontoxic on the basis of human toxic reactions and by an in vivo mouse bioassay. However, it is not currently possible to conclude that affected individuals had specific antibody to ciguatoxin, since putative immune and nonimmune serum samples gave equally clear precipitin reactions with toxic extracts.

(Arch Intern Med 1983;143:1931-1933)