October 1983

Multiple Autoimmune Manifestations in a Splenectomized Subject With HLA-B8

Author Affiliations

From the Department of Medicine B, Soroka University Hospital, and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheba, Israel.

Arch Intern Med. 1983;143(10):1987-1989. doi:10.1001/archinte.1983.00350100171032

• Idiopathic thrombocytopenic purpura developed in a 31-year-old man, and he underwent a splenectomy because of his failure to respond to steroid therapy. Subsequently, during a six-year follow-up, chronic active hepatitis, Coombs' positive hemolytic anemia, and pulmonary interstitial fibrosis developed. Since such a clustering of autoimmune manifestations in a single subject is unusual, possible contributing factors were sought. We suggest that both the splenectomy and the histocompatibility antigen HLA-B8, which the patient was found to carry, may have contributed to this rare clinical syndrome.

(Arch Intern Med 1983;143:1987-1989)