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January 1984

Piroxicam-Induced Renal Disease

Author Affiliations

From the Sections of Nephrology, Reading Hospital and Medical Center, West Reading, and St Joseph Hospital, Reading, Penn.

Arch Intern Med. 1984;144(1):63-64. doi:10.1001/archinte.1984.00350130069014

• Two cases of nephrotoxicity associated with piroxicam therapy are reported. In the first case, severe reversible azotemia with hyperkalemia resolved after discontinuation of the medication. In the second case, biopsy-proved acute interstitial nephritis with immune complex glomerulonephritis and hepatitis improved after steroid therapy. The mechanism for such toxicity may be altered hemodynamics, cellular immunity, or humoral immunity related to prostaglandin inhibition.

(Arch Intern Med 1984;144:63-64)