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January 1984

Pancytopenia and Hepatosplenomegaly in Oxalosis

Author Affiliations

From the Department of Medicine, Case Western University School of Medicine (Dr Hricik), and St John's Hospital (Dr Hussain), Cleveland.

Arch Intern Med. 1984;144(1):167-168. doi:10.1001/archinte.1984.00350130195034

• A 25-year-old woman with oxalosis and end-stage renal disease had pancytopenia and massive hepatosplenomegaly associated with extensive bone marrow deposition of calcium oxalate. A ferrokinetic study suggested profound reduction in erythrocyte production, and peripheral blood smears were compatible with myelophthisis and extramedullary hematopoiesis. Mechanical obliteration of bone marrow by calcium oxalate crystals may lead to pancytopenia and hepatosplenomegaly as late extrarenal complications of oxalosis.

(Arch Intern Med 1984;144:167-168)