February 1984

Endocrine Dysfunction in Chronic Renal Failure

Author Affiliations

From the Neuroendocrine Research Laboratory and Department of Endocrinology, Minneapolis Veterans Administration Medical Center (Dr Morley) and the Division of Endocrinology, Department of Medicine, University of Minnesota, Minneapolis (Dr Mooradian).

Arch Intern Med. 1984;144(2):351-353. doi:10.1001/archinte.1984.00350140175024

• The kidney has a central role in producing and metabolizing a variety of hormones. In addition, chronic renal failure results in alterations in the internal milieu that affects the synthesis and secretory rate of hormones as well as causing alterations of hormone effects on target tissue. Our review highlights the alterations in endocrine function that develop in patients with uremia. Special emphasis is placed on the diagnostic and therapeutic quandaries posed by these alterations in endocrine function.

(Arch Intern Med 1984;144:351-353)