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February 1984

Thyroid Carcinoma in von Hippel-Lindau Disease

Author Affiliations

Hines, Ill

Arch Intern Med. 1984;144(2):413. doi:10.1001/archinte.1984.00350140247037

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To the Editor.  —Von Hippel-Lindau disease is an autosomal dominant disorder commonly characterized by retinal angiomas, cerebellar and spinal hemangioblastomas, renal cell carcinoma, pheochromocytoma, and cystic pancreas, kidneys, and epididymis. Reviews have tabulated close to 40 different pathologic lesions that may be found in this condition.1,2 The following case is reported so that carcinoma of the thyroid gland may be added to the list of characteristics.

Report of a Case.  —A 51-year-old man's condition was diagnosed in 1964 as cerebellar hemangioblastoma. The patient had repeated craniotomies in 1969 and 1975 for recurrent tumor. In 1982, a cervical spinal cord hemangioblastoma was recognized for which a cervical laminectomy was performed. His medical history was also notable for polycystic kidney disease and polycystic pancreas.His final hospitalization was in mid-1983 for the treatment of recurrent aspiration pneumonia; ventilation therapy was started. Other complications included hypertension, renal failure, Pseudomonas sepsis, upper gastrointestinal

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