March 1984

Acute Oligoarthritis Associated With Clostridium difficile Pseudomembranous Colitis

Author Affiliations

From the Department of Medicine, Michigan State University, East Lansing (Dr Lofgren); the Department of Medicine, University of Minnesota, Minneapolis (Drs Tadlock and Soltis); and the Minneapolis Veteran's Administration Hospital (Dr Tadlock).

Arch Intern Med. 1984;144(3):617-619. doi:10.1001/archinte.1984.00350150229045

• The abrupt onset of a sterile inflammatory oligoarthritis developed in a patient with active Clostridium difficile pseudomembranous colitis. The arthritis affected a hip and a knee. Leukocyte counts of synovial fluid obtained from the patient's left hip and knee were elevated. He was haplotyped as HLA-B27 antigen-positive. The colitis and arthritis promptly abated after treatment with oral vancomycin hydrochloride. Three other cases of arthritis associated with antibiotic-induced colitis were reviewed. It seems as if treatment of the colitis leads to resolution of the arthritis.

(Arch Intern Med 1984;144:617-619)