April 1984

Is Streptokinase Safe During Menses?

Author Affiliations

From the Departments of Medicine (Drs Simel, Moorman, and Pryor) and Obstetrics-Gynecology (Dr Piscitelli), Duke University Medical Center, Durham, NC, Veterans Administration Medical Center, West Roxbury, Mass (Dr Sharma), and Harvard Medical School, Boston (Dr Sharma).

Arch Intern Med. 1984;144(4):841-842. doi:10.1001/archinte.1984.00350160211035

• We used intravenous streptokinase to treat a young woman with deep venous thrombosis manifested during her menses. There was no increase in menstrual bleeding, and she was symptom free six months later. Because menstrual endothelium after the first day of menses relies on arteriolar constriction for hemostasis rather than the formation of fibrin, we think that streptokinase may not be contraindicated in thrombotic disorders that occur during menses after the first day.

(Arch Intern Med 1984;144:841-842)