May 1984

Use of Nifedipine as an Adjunct to Current Antihypertensive Therapy

Author Affiliations

From the Departments of Pharmacology (Drs Evans and Cowart) and Pharmacology and Medicine (Drs Olanoff, Hurwitz, and Conradi), Medical University of South Carolina, Charleston. Dr Evans is currently affiliated with the Department of Medicine, Roanoke (Va) Memorial Hospital, and Dr Hurwitz is currently affiliated with the Department of Nuclear Medicine, Barnes Hospital, St Louis.

Arch Intern Med. 1984;144(5):985-987. doi:10.1001/archinte.1984.00350170135023

• Ten hypertensive patients with poor responses to standard antihypertensive therapy were treated with the calcium channel antagonist nifedipine in an attempt to obtain better BP control. The drug was highly effective in significantly lowering BP immediately (average decrease, 58/29 mm Hg) and after three to eight weeks of maintenance therapy (average decrease, 49/27 mm Hg), with no significant change in heart rate observed at either time. No adverse interactions between nifedipine and other concurrent medications, including digoxin and β-adrenergic blockers, were noted. Drug-related side effects of tachycardia or flushing necessitated the withdrawal of nifedipine therapy in two patients. We conclude that nifedipine may be safely employed in an outpatient setting as a useful adjunct to current antihypertensive drug regimens.

(Arch Intern Med 1984;144:985-987)