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Article
May 1984

The Influence of Rifampin on Quinidine and Digoxin

Author Affiliations

From the College of Pharmacy, the University of Texas at Austin (Drs Bussey and Merritt); the Department of Pharmacology, the University of Texas Health Science Center at San Antonio (Drs Bussey and Merritt); and the Department of Neurology, Bowman Gray School of Medicine, Winston-Salem, NC (Dr Hill).

Arch Intern Med. 1984;144(5):1021-1023. doi:10.1001/archinte.1984.00350170183029
Abstract

• Serum drug concentration data from the first of the two patients described herein suggest that rifampin may directly increase the metabolism of quinidine and thereby negate the influence of quinidine on the serum digoxin concentration (SDC). Data on the second patient suggest that rifampin may directly increase the metabolism of digoxin producing lower SDC values. In both cases, the discontinuation of rifampin therapy appears to have allowed reversion toward prerifampin metabolism of both quinidine and digoxin.

(Arch Intern Med 1984;144:1021-1023)

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