July 1984

Serum Inhibitor in Systemic Lupus Erythematosus Associated With Aplastic Anemia

Author Affiliations

From the Department of Medicine, Louisiana State University Medical Center, New Orleans (Drs Brooks, Bryan, and Leech); and the Memorial Sloan-Kettering Cancer Institute, New York (Dr Broxmeyer).

Arch Intern Med. 1984;144(7):1474-1477. doi:10.1001/archinte.1984.00350190172030

• Hematologic complications of systemic lupus erythematosus (SLE) usually involve peripheral destruction of blood elements. We report a case of SLE-associated aplastic anemia in which an IgG complement-dependent antibody, obtained from the patient's disease-phase serum but not remission-phase serum, suppressed growth of granulocyte-macrophage progenitor cells from bone marrow of normal donors in vitro. Therapy with plasmapheresis and immunosuppression resulted in lasting remission.

(Arch Intern Med 1984;144:1474-1477)