July 1984

Factor XII Deficiency in a Man With Gout and Angioimmunoblastic Lymphadenopathy

Author Affiliations

From the Department of Medicine, Mercy Hospital, Pittsburgh. Dr Londino is a rheumatology fellow at St Vincent Hospital, University of Massachusetts Medical Center, Worcester.

Arch Intern Med. 1984;144(7):1497-1498. doi:10.1001/archinte.1984.00350190207035

• A patient with factor XII deficiency, gout, and angioimmunoblastic lymphadenopathy (AIL) was seen initially for an acute myocardial infarction, gout, and unexplained urticaria. The patient eventually was found to have AIL and a prolonged partial thromboplastin time. There was no evidence of a circulating anticoagulant. A factor XII deficiency (Hageman factor) was discovered. The coexistence of a factor XII deficiency, AIL, and gout in the same person raises some interesting questions regarding the basic mechanisms of the inflammatory process.

(Arch Intern Med 1984;144:1497-1498)