July 1984

Multiple Autoimmune Endocrinopathy Including Pituitary Adrenocorticotropic Hormone Cells?

Author Affiliations

Curacao, Antilles

Arch Intern Med. 1984;144(7):1505. doi:10.1001/archinte.1984.00350190215038

To the Editor.  —I read the article by Mazzone et al1 with much interest, because, for some five years I treated a 48-year-old man with proved pernicious anemia, primary hypothyroidism, and an isolated deficiency of adrenocorticotropic hormone (ACTH). Antibodies against parietal cells and thyroid microsomes were strongly positive. A preliminary investigation of his serum samples by Pouplard et al2 at Middlesex Hospital, London, was positive for antibodies against pituitary cells. This case will be published within a few months, when more specific tests for ACTH producing—cell antibodies have been accomplished.To my knowledge, this will be the first reported case of a patient with clinical and laboratory symptoms of multiple autoimmune endocrinopathy. Five years following diagnosis, the patient is well and continuing triple substitution therapy.

First Page Preview View Large
First page PDF preview
First page PDF preview