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August 1984

Oral Manifestations of Chronic Graft-v-Host Disease

Author Affiliations

From the Departments of Medicine (Drs Sullivan, Buckner, Storb, and Thomas), Oral Medicine (Drs Schubert, Izutsu, Peterson, and Truelove), Pathology (Dr Sale), and Oral Pathology (Dr Morton), University of Washington Schools of Medicine and Dentistry and the Fred Hutchinson Cancer Research Center (Drs Schubert, Sullivan, Flournoy, Sale, Buckner, Storb, and Thomas), Seattle.

Arch Intern Med. 1984;144(8):1591-1595. doi:10.1001/archinte.1984.00350200087014

• Sixty patients were studied 180 to 500 days after allogeneic marrow transplantation to determine if late oral abnormalities were associated with the presence of chronic graft-v-host disease (GVHD). Lip and intraoral mucosal surfaces were evaluated for color, keratinization, atrophy, and erythema. Subjective complaints of oral pain and xerostomia were also recorded. Abnormalities were scored on a scale of 0 to 3 and tested for association with GVHD by χ2 test. Oral manifestations most strongly associated with chronic GVHD included atrophy and erythema or lichenoid lesions of the buccal and labial mucosa and oral pain. Oral manifestations resembled several naturally occurring autoimmune disorders. Recognition of these changes can aid in the clinical diagnosis and assessment of established chronic GVHD.

(Arch Intern Med 1984;144:1591-1595)