August 1984

The Effect of Single-Dose Methyldopa and Diuretic on BP and Left Ventricular Mass

Author Affiliations

From the Jerusalem Heart Clinic, the Health Insurance Institution of the General Federation of Labor in Israel.

Arch Intern Med. 1984;144(8):1629-1632. doi:10.1001/archinte.1984.00350200139020

• The effect of a single daily dose of 500 mg of methyldopa with 50 mg of hydrochlorothiazide and 5 mg of amiloride hydrochloride was studied in 21 patients with mild to moderate hypertension. It was shown that the average morning BP changed from 182/103±15/9 mm Hg to 145/83±16/8 mm Hg following one day of treatment. Similarly, the average of seven hourly measurements (7BP) dropped from 170/99±11/7 mm Hg to 145/86±11/8 mm Hg. In 12 patients, the same therapy lowered the morning BP from 186/104±16/9 mm Hg to 144/83±15/8 mm Hg and the 7BP from 168/98±10/6 mm Hg to 142/83±12/7 mm Hg following three weeks. After eight weeks, normal values were still maintained. Left ventricular mass was elevated in all the patients (330±67) and dropped by an average of 12% and 17% by three and eight weeks after initiation of therapy. Unchanged left ventricular end diastolic volume and decreased muscle thickness indicate true reduction in hypertrophy in addition to the BP-lowering effect of this combined single-dose therapy described.

(Arch Intern Med 1984;144:1629-1632)