September 1984

Salivary ?-Glutamyl Transferase Activity in Internal Diseases

Author Affiliations

From the Department of Internal Medicine (Drs Jiménez-Alonso, Barrios, Peréz-Jimérez, Costan, and Jiménez-Perepérez) and Clinical Chemistry Laboratory (Dr Jaimez), Hospital and Medical School, Reina Sofía, Córdoba, Spain.

Arch Intern Med. 1984;144(9):1804-1806. doi:10.1001/archinte.1984.00350210126022

• Salivary γ-glutamyl transferase (GGT) activity was measured in 116 patients with several diseases that involved the hepatobillary tract, pancreas, and miscellaneous disorders and in 20 normal subjects. We have found significantly elevated values of salivary GGT in cirrhosis of the liver (8.3 ± 0.9 [mean ± SEM] units/L), hepatic tumors (10.4 ± 1.3 units/L), acute cholecystitis (18.3 ± 2 units/L), acute pancreatitis (15.1 ± 2.4 units/L), diabetic ketoacidosis (11.6 ± 1 units/L), and Sjögren's syndrome (19.6 ± 4.8 units/L). Salivary GGT activities were unmodified in fatty liver, infectious hepatitis, silent cholelithiasis, and mumps. Several mechanisms explain high salivary GGT activity. Measurement of salivary GGT activity in internal medicine merits further investigations to determine its potential diagnostic value.

(Arch Intern Med 1984;144:1804-1806)