November 1984

Disseminated Histoplasmosis in Patients With the Acquired Immune Deficiency Syndrome

Author Affiliations

From the Departments of Medicine (Drs Bonner, Alexander, Dismukes, App, Griffin, and Little) and Radiology (Dr Shin), University of Alabama in Birmingham.

Arch Intern Med. 1984;144(11):2178-2181. doi:10.1001/archinte.1984.04400020088014

• The ongoing epidemic of acquired immune deficiency syndrome (AIDS) has affected homosexual men, intravenous (IV) drug abusers, Haitians, hemophiliacs, and others. Defects in cell-mediated immunity place these patients at risk for opportunistic infections. We recently saw three men from Alabama with disseminated infection due to Histoplasma capsulatum. Two of these men were homosexual and the other was an IV drug abuser. These three patients had evidence of depressed cellular immunity consistent with a diagnosis of AIDS. Infection caused by organisms indigenous to certain geographic areas of the United States may become more common in patients with AIDS as the epidemic continues.

(Arch Intern Med 1984;144:2178-2181)