January 1985

Serum ?-Glutamyl Transferase Activity in Thyrotoxicosis

Arch Intern Med. 1985;145(1):179. doi:10.1001/archinte.1985.00360010227048

To the Editor.  —We read with interest the article by Azizi1 in the January Archives and the letter by JiménezAlonso et al2 and Azizi's reply.3 We can confirm Azizi's data in a greater number of patients, at least in part.We, too, have studied the serum γ-glutamyl transferase (GGT) levels in untreated Graves' disease (44 patients) and Plummer's disease (ten patients). Our patients were compared with 100 healthy, age- and sex-matched control subjects. The diagnosis of thyrotoxicosis was based on clinical findings and measurement of serum triiodothyronine (T3) and thyroxine (T4) by radioimmunoassay, T3 resin uptake (T3RU), (free T4 index [FT4I] and free T3 index [FT3I] were calculated [T3xT3 RU, T4xT3 RU, respectively]), radioiodine uptake of thyroid at two and 24 hours, and scintiscans (with or without thyrotropin given previously), for patients and controls, respectively. Serum GGT was assayed by a commercial GGT test (Boehringer/Ingelheim, FRG) based on

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