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February 1985

Abnormal Thyrotropin and Prolactin Levels in Untreated Corticotropin Deficiency

Author Affiliations

From the Departments of Medicine, University of North Carolina School of Medicine and New Hanover Memorial Hospital, Wilmington, NC.

Arch Intern Med. 1985;145(2):356-357. doi:10.1001/archinte.1985.00360020200035

• A patient with isolated corticotropin deficiency demonstrated hyperresponsiveness of both thyrotropin and prolactin after protirelin stimulation. Following glucocorticoid replacement therapy, responses decreased to normal. Since true primary hypothyroidism may occur in association with cortisol-deficient states, it is necessary to reserve final evaluation until after glucocorticoid replacement. The finding of combined thyrotropin and prolactin hyperresponsiveness to protirelin suggests a related glucocorticoid feedback function.

(Arch Intern Med 1985;145:356-357)