March 1985

B-Cell Lymphoma in Two Monogamous Homosexual Men

Author Affiliations

From the Section of Hematology, Department of Medicine (Drs Levine, Burkes, Walker, and Gill and Ms Dworsky), and the Section of Hematopathology, Department of Pathology (Drs Meyer, Nichols, Parker, and Lukes), Los Angeles County—University of Southern California Medical Center, Los Angeles.

Arch Intern Med. 1985;145(3):479-481. doi:10.1001/archinte.1985.00360030123022

• Opportunistic infections and malignant neoplasms have been described in homosexual men in association with immunologic abnormalities. We observed the development of malignant B-cell lymphomas in two homosexual men who had had a monogamous relationship for two years. Patient 1 had an aggressive, monoclonal, small, noncleaved, non-Burkitt's lymphoma ("undifferentiated lymphoma"), associated with severe immunocompromise. Patient 2 manifested a monoclonal, small, cleaved, follicular center cell lymphoma, with a follicular pattern, two months later. No common acute infection was detected. Staining for Epstein-Barr nuclear antigen in malignant tissue was negative in the second patient. However, the possibility of a transmissible agent as a causative factor cannot be excluded, and further study of similar patients is warranted.

(Arch Intern Med 1985;145:479-481)