April 1985

Phenylbutazone-Induced Systemic Vasculitis With Crescentic Glomerulonephritis

Author Affiliations

From the Renal Unit (Drs Leung, Dobbie, and Boulton Jones) and the Department of Pathology (Dr McLay), Royal Infirmary, Glasgow, Scotland.

Arch Intern Med. 1985;145(4):685-687. doi:10.1001/archinte.1985.00360040109024

• Two patients had phenylbutazone-induced systemic vasculitis syndrome. Both presented with acute oliguric renal failure, and renal biopsies showed severe crescentic glomerulonephritis with marked interstitial inflammatory cell infiltration. Withdrawal of phenylbutazone and treatment with immunosuppressives and plasma exchange led to recovery of renal function in one case.

(Arch Intern Med 1985;145:685-687)