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April 1985

Hepatic Vein Obstruction in Idiopathic Hypereosinophilic Syndrome

Author Affiliations

From the Research Unit Inserm 99, Hepatology and Gastroenterology Service (Drs Elouaer-Blanc, Saint-Marc Girardin, and Dhumeaux); Pathology Service (Dr Zafrani); Hematology Service (Dr Farcet); and Radiology Service (Dr Mathieu), Henri Mondor Hospital, Créteil, France.

Arch Intern Med. 1985;145(4):751-753. doi:10.1001/archinte.1985.00360040189042

• We report an association between idiopathic hypereosinophilic syndrome and obstruction of the hepatic veins (Budd-Chiari syndrome). Budd-Chiari syndrome was assessed by liver biopsy and hepatic phlebography and documented by computed tomography. Postmortem examination revealed fibrous occlusion of the hepatic venous tree, as well as fibrosis of the endocardium and of myocardial and pulmonary vessels. To our knowledge, the association between idiopathic hypereosinophilic syndrome and Budd-Chiari syndrome has never previously been reported. Since it has been suggested that hypereosinophilia might cause endothelium damage, a link between these two entities is postulated.

(Arch Intern Med 1985;145:751-753)