June 1985

Plasma Concentrations of Fibrinopeptide A and Fibrinopeptide Bß15-42 in Glomerulonephritis and the Nephrotic Syndrome

Author Affiliations

From the Department of Internal Medicine, Tokyo Medical and Dental University (Drs Tomura, Kuriyama, and Takeuchi), and the Department of Clinical Chemistry, Special Reference Laboratory, Tokyo (Mr Oono). Dr Tomura is now with the Division of Nephrology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, Calif.

Arch Intern Med. 1985;145(6):1033-1035. doi:10.1001/archinte.1985.00360060097014

• Plasma fibrinopeptide A (FPA) and fibrinopeptide Bβ15-42 concentrations were determined by radioimmunoassay in 46 patients with glomerulonephritis and the nephrotic syndrome. An increase in plasma FPA and Bβ15-42 levels was noted in these patients; this increase was marked in the nephrotic patients. There was a positive correlation in these patients between plasma FPA and Bβ15-42 levels. The Bβ15-42/FPA ratio was significantly higher in nonnephrotic patients compared with controls. Intravascular coagulation with subsequent fibrinolysis to regulate fibrin formation may occur in patients. A positive correlation was found between plasma Bβ15-42 level and serum urea nitrogen or serum creatinine concentration, suggesting that plasma Bβ15-42 level is influenced not only by plasmin action, but also by renal dysfunction.

(Arch Intern Med 1985;145:1033-1035)