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August 1985

Open Lung Biopsy in Immunocompromised Patients

Author Affiliations

From the Divisions of Infectious Diseases and Internal Medicine (Drs Cockerill and Wilson) and of Thoracic Diseases and Internal Medicine (Dr Rosenow), and the Sections of Surgical Pathology (Dr Carpenter) and Clinical Microbiology (Dr Smith), Mayo Clinic and Mayo Foundation, Rochester, Minn.

Arch Intern Med. 1985;145(8):1398-1404. doi:10.1001/archinte.1985.00360080068009

• From January 1978 through December 1980, ninety-five immunocompromised patients underwent diagnostic open lung biopsy (OLB) at the Mayo Clinic, Rochester, Minn. A specific causative diagnosis was made in 77 patients (81%); 12 patients (13%) had more than one specific causative diagnosis. Of the 77 patients with a specific causative diagnosis, 52 patients (68%) had infections, 19 patients (24%) had malignant pulmonary disease, 12 patients (15%) had cytotoxic lung disease, ten patients (13%) had interstitial fibrosis (not related to cytotoxins), and one patient (1%) had vasculitis. In 36 (47%) of the 77 patients with a specific causative diagnosis, the diagnosis was made, by frozen sections or stains, within three hours of OLB. In 35 additional patients (45%), the diagnosis was established within 24 hours. Twelve patients (13%) had minor complications of OLB; no deaths were attributed to the OLB procedure.

(Arch Intern Med 1985;145:1398-1404)