August 1985

Immune Hemolytic Anemia Associated With Sulindac

Author Affiliations

From the Departments of Pathology (Dr Johnson and Mr Liesch) and Internal Medicine (Dr Hamilton), University of Iowa Hospitals and Clinics, Iowa City.

Arch Intern Med. 1985;145(8):1515-1516. doi:10.1001/archinte.1985.00360080197030

• A number of adverse reactions have been associated with sulindac, a nonsteroidal anti-inflammatory drug, but acute hemolytic anemia associated with sulindac has not yet been reported, to our knowledge. We encountered two cases of severe immune hemolytic anemia, one fatal, which appear to have been related to sulindac. In vitro studies provided evidence that antibodies to sulindac and its metabolites were present in the serum of both patients.

(Arch Intern Med 1985;145:1515-1516)