October 1985

Escherichia coli Bacteremia, Meningitis, and Hemochromatosis

Author Affiliations

From the Department of Medicine, Hackley and Mercy Hospitals, Muskegon, Mich.

Arch Intern Med. 1985;145(10):1908. doi:10.1001/archinte.1985.00360100178031

• A 67-year-old man with Escherichia coli bacteremia and meningitis was found to have hemochromatosis. To my knowledge this is the first documented case of E coli meningitis occurring in the setting of hemochromatosis. The case raises issues regarding the role of chronic liver disease in the pathogenesis of gram-negative sepsis and the impact of iron loading on host immunocompetence and bacterial virulence.

(Arch Intern Med 1985;145:1908)