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Article
November 1985

Renal Handling of Urate in the Syndrome of Inappropriate Secretion of Antidiuretic Hormone

Author Affiliations

From the Department of Internal Medicine, Yokosuka Mutual Aid Hospital, Kanagawa, Japan (Drs Shichiri, Kijima, and Kanayama) and the Second Department of Internal Medicine, Tokyo Medical and Dental University (Drs Shinoda and Shiigai). Dr Shichiri is now with the Tokyo Medical and Dental University.

Arch Intern Med. 1985;145(11):2045-2047. doi:10.1001/archinte.1985.00360110119025
Abstract

• Three patients with the syndrome of inappropriate secretion of antidiuretic hormone had elevated uric acid clearances. Their uric acid clearances decreased markedly after the administration of pyrazinamide. Probenecid was given to two of them and it produced large increases in uric acid clearance. These data suggest that enhanced secretion in the renal tubules was responsible for the increased clearance of uric acid. This article provides evidence that hypouricemia in the syndrome of inappropriate secretion of antidiuretic hormone is due to increased tubular urate secretion.

(Arch Intern Med 1985;145:2045-2047)

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