January 1986

A Review of Nephrotic Syndrome Associated With Chronic Lymphocytic Leukemia

Author Affiliations

From the Departments of Medicine (Drs Seney and Stein) and Pathology (Drs Federgreen and Kashgarian), Yale University School of Medicine, New Haven, Conn, and the Veterans Administration Hospital, West Haven, Conn. Dr Seney is a fellow in the Section of Nephrology, Yale University. Dr Stein is now at Abington (Pa) Memorial Hospital. Dr Seney is now with the Department of Medicine, University of Texas Health Science Center at Dallas.

Arch Intern Med. 1986;146(1):137-141. doi:10.1001/archinte.1986.00360130167023

Four patients had the nephrotic syndrome and chronic lymphocytic leukemia (CLL), which may be pathogenetically related. Membranoproliferative glomerulonephritis appears to be the most common glomerular lesion in patients with CLL. Available evidence suggests that nephrotic syndrome associated with CLL is often related to immune-complex disease. It is also possible that disorders of immunoglobulin production and cellular immunity contribute to renal disease in patients with CLL.

(Arch Intern Med 1986;146:137-141)